Sunday, January 15, 2012

Angelina Jolie, Pedro Almodovar may soon collaborate (Reuters)

LOS ANGELES (Reuters) ? First-time director Angelina Jolie and Spanish filmmaker Pedro Almodovar made the most of an afternoon red-carpet event on Saturday, playfully striking a deal to work together on a movie.

Jolie and Almodovar were speaking separately to reporters at the American Cinematheque's annual event for the Golden Globe Awards' foreign-language nominees, when they took a break from interviews to greet each other and talk shop.

Almodovar joked about improving his English and then eagerly agreed when Jolie expressed an interest in working with him.

"So you promise, one day? When all these cameras are gone, we'll find a film together?" Jolie asked Almodovar, to which he responded, "Yes. Absolutely."

In the meantime, the future filmmaking collaborators have a busy awards season. Both have films in the running in the foreign-language category at Sunday's Golden Globes Awards in Los Angeles.

Jolie's "In the Land of Blood and Honey," a drama about the Bosnian War of the 1990s with dialogue in Serbo-Croatian, and Almodovar's sci-fi-tinged thriller "The Skin I Live In" are both nominated.

Their fellow nominees are Asghar Farhadi's "A Separation," from Iran, Chinese director Zhang Yimou's "The Flowers of War" and the Belgian drama "The Kid With a Bike," by sibling filmmakers Luc Dardenne and Jean-Pierre Dardenne.

(Editing by Bob Tourtellotte)

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/nm/20120115/film_nm/us_angelinajolie_pedroalmodovar

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Razer Naga Hex gaming mouse ? Coolest Gadgets

by Edwin - on January 12th, 2012

Gaming is serious business, and for those who take their frags and RTS strategies seriously, then surely high-end hardware is the name of the game for such gamers. CES 2012 proved to be a potent platform for Razer to continue with their serpentine collection of gaming peripherals, with the latest one being the Razer Naga Hex gaming mouse. Yes sir, their latest gaming mouse will feature half a dozen thumb buttons that was specially designed for MOBA (Multiplayer Online Battle Arena), action-RPG and hack and slash genres.

The inspiration behind the Naga Hex? Its predecessor of sorts, the award-winning Razer Naga MMO gaming mouse came with a 12-button thumb grid, so the Razer Naga Hex now sports six large thumb buttons that have been optimized for the user interfaces found in action-RPG and MOBA games.

All of the six mechanical buttons can be bound to specific spells, abilities, items, and other invaluable commands in MOBA games such as League of Legends. This alone paves the way for faster and easier actuation, where a mechanical key infrastructure that uses less force to actuate allows you to have the upper hand in terms of speed over your enemies. This results in you being able to strike them before they can react, pretty much in the same way most snakes attack with lightning fast reflexes. Not only that, with Diablo III more or less ready to roll out in due time (not taking as long as Duke Nukem forever, I hope), you can prepare yourself by getting the Razer Naga Hex beforehand since it is perfect for obsessive clicking in hack and slash games.

Special switches are used in the construction of the Razer Naga Hex?s buttons, where they are able to withstand up to 250 clicks per minute ? if you average that out, it amounts to slightly more than 4 clicks a second. Fret not about hyper-clicking though, as the Razer Naga Hex is said to be good for up to a whopping 10 million clicks ? that translates to 40,000 minutes, which leads us to 666 hours if you decide to break it down further ? now that is a whole lot of clicks (and a diabolical number to boot), so chances are you would settle for a new mouse long before the Naga Hex bites the proverbial dust.

Nice to know the asking price for the Razer Naga Hex gaming mouse is not that high either at just $79.99, where it will ship from the end of this month onwards.

Press Release

Source: http://www.coolest-gadgets.com/20120112/razer-naga-hex-gaming-mouse/

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Saturday, January 14, 2012

Daily Crunch: Vision

1519Here are some of yesterday’s highlights at CES on TechCrunch Gadgets: Hands On: The Nintendo Wii U TC/Gadgets Interview: Up Close With The Lytro 50 Cent Weighs In: Waterproof Phones And Fighting Poverty Vuzix: SMART Glasses Explained Why Samsung Is The Next Apple

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Bh1NX5ew8Ww/

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Insight: Foreign banks squeeze costs as Asia's glow fades (Reuters)

HONG KONG (Reuters) ? Big Wall Street and European banks are looking to slash budgets across Asia, as the emerging market promise is trumped by an urgent need to control costs.

From taxi and air fares and year-end parties to entire operational divisions and new country offices, little is sacred.

The age of headquarters in New York or London subsidizing investment banking expansion in Asia is giving way to a period of austerity - a shift the industry accepts is long-term, especially given a steep drop in Asia fee income late last year compared to the rest of the world.

The cost cutting goes beyond standard headcount reductions, scything deep inside banks, where whole product teams are being closed down, entire offices are under review, and travel and entertainment budgets are pared to the bone.

Hiring is sparse, with pressure from bank headquarters to first show results for those who joined in the past two years. Division heads are no longer chasing every deal, and instead have to be much more selective.

"The heyday of just expanding and taking people wholesale is over," said Enid Yip, Asia Chief Executive at Swiss private bank Sarasin. "People will have to start looking very closely at their own contribution to the P&L (profit and loss)."

In Asia, estimated fee volumes slumped 43 percent in October-December, the biggest drop of any region, though the others were not far behind. With Asia excluding Japan accounting for only 15 percent of the global fee pool, any continued fall on last year's scale just damages the Asia proposition further.

"Last year, a $1 billion deal turned into $300 million, if it went through at all. A $10 million fee suddenly became $1 million. We have to be more selective about where we put resources," said an Asia head at one U.S. investment bank.

Bank of America-Merrill Lynch is shedding a fifth of its investment banking managing directors in Asia this quarter, and is pooling some analysts and associates to respond to business that is critical, rather than have them in specific teams, sources have said.

Credit Suisse is closing its Taiwan fixed income operations, and Macquarie closed part of its equity derivatives division in Hong Kong in the fall.

Spanish bank BBVA, which was expanding rapidly until mid-last year, has cut about a third of its wholesale banking staff in Asia, and Morgan Stanley has chopped fixed-income jobs in Singapore and Hong Kong, sources told Reuters.

The abrupt exit of Jesse Bhattal from Japanese brokerage Nomura Holdings, announced this week, helps underscore the point. Bhattal led Lehman Brothers and Nomura at a time of heady expansion and leaves now when the growth period is ending.

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GRAPHIC: Investment bank fees: http://r.reuters.com/ryf95s

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Facing weak markets and tougher regulation, global banks have outlined plans to cut more than 125,000 jobs this year, according to a Reuters tally. Until recently, Asia had largely been untouched by the jobs axe.

Domestic Asian banks such as the top Chinese lenders, once held up as the ultimate growth story, are also seeing earnings slow, ratcheting up the pressure on them to rein in costs.

Globally, diversified banks are expected to report a 14 percent rise in earnings this year, according to Thomson Reuters Starmine data. Asian banks are expected to underperform that, with earnings rising only 8.5 percent.

While some investment banks with large commercial operations are seeing their share of Asia profits increase, most are running the rule over their operations, with research divisions, sales and trading desks and even country offices such as in India, South Korea and Taiwan under scrutiny, according to senior Asia bank executives interviewed by Reuters.

INDIA, TAIWAN ON RADAR

India, because of the number of banks operating there and the notoriously low fees paid, is a prime target for scaling down by Asia banks. Political dysfunction, slowing growth and a weaker rupee have forced some to re-examine their operations in a country that had been held up as the next growth story.

Estimated investment banking fees in India dropped by a third last year to $863 million, according to Thomson Reuters data. Asia was the worst performing region globally, down 12.5 percent in Asia Pacific, while fees in Europe and the Americas fell about 3 percent.

Asia-focused Standard Chartered has begun warning of slowing growth in India, which in 2010 was the bank's largest profit earner. It now lags behind Hong Kong and Singapore.

"India is going to be slow by any benchmark over 2012," the bank's Asia CEO Jaspal Bindra told Reuters. "There are mines out there, including the big 2014 elections, which will hopefully throw up a government that will have more authority in policy making."

Taiwan is also in banks' firing line, with an activist regulator, overbanked market and touchy companies happy to take banks to court at the slightest bit of irritation. A win by the independence-leaning Democratic Progressive Party in this week's presidential elections could worsen ties with China - and prompt banks to further look into their operations on the island.

Research departments, in particular, face cutbacks. They are in many cases the most public face of many investment banks, but tend to be a high cost with little clear effect on earnings.

They are also the most open to fractured ties with potential clients. HTC, the world's No.4 smartphone maker, is suing Citigroup's Taiwan unit, saying the bank published false information that triggered a fall in the company's shares.

Privately, many leading analysts say it's now increasingly difficult to convince their bosses to hire as trading volumes remain largely flat in Asia's major bourses such as Hong Kong and Tokyo.

Top Asian companies such as ICBC and PetroChina are covered by as many analysts as Apple, according to Thomson One Analytics, yet turnover in the iPhone and iPad maker's shares is more than 10 times that of ICBC.

SHRINKING FEES

Foreign banks have also felt the squeeze from Asian currencies weakening against the U.S. dollar. Most banks report their earnings in dollars. China saw investment banking fees slide by a quarter in 2011. Even developed economies like Japan and Singapore saw fees fall more than 12 percent, Thomson Reuters data show.

"Three or four years ago, we could have argued for another India office, or maybe build up Manila," said the Hong Kong-based head of a division at a top Wall Street investment bank, who did not want to be named as he was not authorized to talk to the media.

"The bar is much higher now. The idea of New York subsidizing Asia's growth is gone. The filter with which they assess our expansion requests is thicker."

By one estimate, salary raises for Hong Kong bankers outpace their peers in the City of London, with basic pay up 15 percent in 2011, compared to 12 percent in Britain, according to recruitment firm Astbury Marsden.

As fees decline, higher pay in Asia is harder to justify, unlike in recent years when strong capital markets kept business flowing throughout the year.

The squeeze on costs in the region is tightening.

Staff at Indian brokerage Religare Securities were told in a memo late last year that they could no longer claim taxi fares when working weekends. Managing directors at J.P. Morgan chipped in to help pay for the Hong Kong Christmas party.

Economy class flights are now mandatory on the popular Hong Kong to Singapore route at several banks.

Spokespeople at the banks declined to comment for this article on the specifics of their travel, entertainment or compensation policies.

Some investment bankers and executives interviewed said the return to a sharper focus, with tighter budgets, is probably a good thing.

"I think there are more opportunities to be able to attract talented people without those superfluous payments that we had to make in the past when the market was very hot," said StanChart's Bindra.

(Editing by Ian Geoghegan)

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/nm/20120112/bs_nm/us_banks_costs_asia

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Friday, January 13, 2012

Gut microbe networks differ from norm in obese people, systems biology approach reveals

Gut microbe networks differ from norm in obese people, systems biology approach reveals

Wednesday, January 11, 2012

For the first time, researchers have analyzed the multitude of microorganisms residing in the human gut as a complex, integrated biological system, rather than a set of separate species. Their approach has revealed patterns that correspond with excess body weight.

The collection of microbes inside the human gut is a bustling network of genetic interplays and energy use. By constructing models of these microbial communities, scientists have discovered novel differences between obese and lean people.

They were able to detect organizational shifts away from a normal "lean" state in the gut flora of people who were significantly overweight, as well as in people with inflammatory bowel disease. The findings are reported in the Proceedings of the National Academy of Sciences.

The senior author of the paper, Elhanan Borenstein, assistant professor of genome sciences at the University of Washington, said, "Our research introduces a novel framework, applying systems biology and in-silico (computer) modeling to study the human microbiome ? the complex ensemble of microorganisms that populate the human body ? as a single cohesive system."

Sharon Greenblum of the UW Department of Genome Sciences and Peter J. Turnbaugh of the FAS Center for Systems Biology at Harvard University were on the research team. Borenstein also holds an adjunct appointment at the UW's Department of Computer Science & Engineering and is an External Professor at the Santa Fe Institute.

The team's approach is to treat the human microbiome as a cohesive "supra-organism," in which genes from multiple microbial species act in concert, as if they were part of a single organism.

World-wide research initiatives, Borenstein said, highlight how the microbiome influences human health. The microbiome is essential for human development, immunity and nutrition.

People harbor more than 100 trillion microbes. These microbes live in various habitats on and within the human anatomy; the gut houses the densest population of all, containing hundreds of bacterial species. Their collective gene set is enormous: 150 times larger than the set of human genes.

The gut microbiome helps keep us alive by manufacturing vitamins and the building blocks of proteins, extracting energy from food, and conferring disease resistance. Previous research on the gut microbiome, including the transfer of a donor microbiome to a recipient, suggests that manipulation of the gut flora may have useful clinical applications.

"Characterizing the gut microbiome and its interactions with its human host has the potential to provide deep insight into normal human physiology and disease states," said Greenblum, the first author on the paper.

Researchers mapping the human microbiome are discovering previously uncharted species and genes. Genetic studies determining the relative abundance of different species in the human microbiome have linked various combinations of species to certain human conditions. Researchers have already observed that obese and lean people have differences in their gut microbiome.

What preliminary findings are still missing, according to Borenstein, is a comprehensive, system-level understanding of how these variations in the genetic makeup of the microbiome affect its organization and consequently its metabolic potential (energy production, use and storage) and its effects on the human host.

Borenstein's team obtained datasets derived from two previous studies describing the set of genes in the gut microbiomes of lean and obese individuals and patients with inflammatory bowel disease.

The team used advanced computational techniques to reconstruct models of these microbial communities and the interactions between the various genes. The group also estimated the change in abundance of enzymes associated with the various host states: lean, obese, or affected with inflammatory bowel disease.

Their models reflected metabolic interdependencies between enzymes, not their physical location in the gut. Certain interactions were central to the microbial community's metabolism. However, those enzymes that typified obesity or leanness were mostly remote from the core network and its key metabolic functions. These enzymes worked in the periphery of the modeled network. These peripheral enzymes may represent metabolic first steps relying on substances not manufactured by the microbiome or end points releasing products not used by the microbiome, the researchers surmised.

Such enzymes, Borenstein explained, are likely to directly use or produce substances that characterize the gut environment, and form an interface between microbial and human metabolism.

"Our results suggest that the enzyme-level variation associated with obesity and inflammatory bowel disease relates to changes in how the microbiome interacts with the human gut environment, rather than a variation in the microbiome's core metabolic processes," Borenstein said.

He said other findings point to the obese microbiomes' potential ability to use diverse energy sources, which may account for their increased capacity to extract energy from the diet. This system approach also suggests possible biomarkers for obesity and inflammatory bowel disease. The markers may indicate common underlying triggers of disease or a response of the gut microbiome to disease.

Comparisons between the obese and lean microbiome network models also showed that obese microbiomes are associated with lower levels of a topological trait called "modularity." The reduced modularity of obese microbiome communities resembles that of single species that inhabit more constant environments.

While the associations drawn from the study may not clearly implicate a specific mechanism for complex and poorly understood diseases such as obesity and inflammatory bowel disease, Borenstein noted that they demonstrate the promise of using a systems biology approach to study the human microbiome and its contribution to human health.

###

University of Washington: http://www.uwnews.org

Thanks to University of Washington for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/116624/Gut_microbe_networks_differ_from_norm_in_obese_people__systems_biology_approach_reveals

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Thursday, January 12, 2012

Motorola Droid 4 hands-on

Motorola Droid 4

The worst-kept secret of the season has got to be the Motorola Droid 4 on Verizon. And here it is in our hot little hands. The Big Deal here is that the keyboard once again has been redesigned. The keys are now laser cut (as opposed to whatever medieval method was used previously), and they're backlit. And they're pretty nice. Maybe a tad slick, but they're also pretty new. The backlight's definitely a nice touch.

The other surprising feature on the Droid 4 is its weight. Or, lack thereof. Whereas the previous members of the Droid line were, more or less, known for their heft, the Droid 4 is surprisingly light. You're not going to mistake it for a RAZR anytime soon, but it's not going to cause you to list to one side while you're walking.

One odd feature: The battery door is removable so you can get to the SIM card. But the battery itself is not removable.

The slider mechanism is decent enough, and Motorola's implementation of Gingerbread is speedy and full of features like MOTOCAST and Smart Actions, and all the business-type software Moto can muster. The suits are going to love it. The IT department is going to love it. And even after brief use, we're pretty sure we're going to be pretty pleased with it.

The only question we have is this: How long until the Droid 5?

We've got a full hands-on after the break.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/xyMRSZKCiL8/story01.htm

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Wednesday, January 11, 2012

Three Ice Cream Sandwich Tablets for 2012 (ContributorNetwork)

Tablets powered by Android -- Google's open-source operating system for smartphones and tablets -- failed to make much of a splash in 2011. The iPad simply eclipsed them all put together, and then HP won the sales race for also-rans when it put its TouchPad on sale for $99.

Only the Kindle Fire and Nook Color/Nook Tablet managed to sell very well against the iPad. Both are powered by Android "under the hood," but neither run Ice Cream Sandwich, the latest version of Android, which introduces many new features and solves most of the bugs that Honeycomb had.

Here are three confirmed tablets that will run the "full" Ice Cream Sandwich version of Android, and will be available soon.

Acer Iconia Tab A200

What does the new Iconia Tab have going for it, to put it ahead of the pack? A 10.1-inch screen and a $349 price tag for the standard 16 GB version. (An 8 GB version will also be available for $329.)

According to Geoff Duncan of Digital Trends, it will come with Android 3.2 Honeycomb when it launches on Jan. 15, but will be "upgradable" to Ice Cream Sandwich in February. Its other stats are typical of last year's high-end Android tablets, except for its full-size USB port.

Toshiba Excite X10

Cameron Summerson of Android Police had a hands-on preview of this upcoming tablet, which is "expected to be available" sometime in the first quarter. It will have a 1.2 GHz dual-core processor, 1 GB of RAM and a 10.1-inch display. MicroSD and miniHDMI ports are standard. Prices will start at $530 for the 16 GB model, and it will come with Android 3.2 and be "Ice Cream Sandwich ready."

So what makes the Excite X10 worth its price tag? That's debatable, but at only 7.7 millimeters thick it'll be the thinnest tablet in the world when it comes out.

Lenovo IdeaTab K2

Brandon Lancaster of Android Police summarizes Engadget's hands-on: This 10-inch behemoth has a 1,920-by-1,200 IPS display, with more than twice the resolution of a normal 10-inch tablet and full non-washed out color from any angle. It also has a Tegra 3 quad-core processor and Android 4.0 Ice Cream Sandwich out of the box, plus a fingerprint scanner that can be used as a mouse-style pointing device (or will be once it's ready).

According to Engadget's Richard Lai, however, the IdeaTab K2 will be released in China first. There's no word yet on when it will reach the States or how much it will cost. But with those specs, it will probably be expensive, as it's "aimed at high-end business users".

Jared Spurbeck is an open-source software enthusiast, who uses an Android phone and an Ubuntu laptop PC. He has been writing about technology and electronics since 2008.

Source: http://us.rd.yahoo.com/dailynews/rss/applecomputer/*http%3A//news.yahoo.com/s/ac/20120109/tc_ac/10809789_three_ice_cream_sandwich_tablets_for2012

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